Journal Issue: Vol 12, No 2 - April 2013

Displaying 1 - 10 of 10

« View All Issues


Editorial - Major Radiation Oncology Advances 2012 in China

Dr Huiming Yu, Dr Guangying Zhu

  1. Dr Huiming Yu
    Department of Radiation Oncology, Chaoyang Hospital, Capital Medical University, Beijing.
  2. Dr Guangying Zhu
    Department of Radiation Oncology, Cancer Hospital, Peking University, Beijing, 100142

With the improvement of the accuracy in radiation therapy, radiotherapy is playing a more and more important role in the treatment of tumors. According to the WHO statistics, almost half of the cure of tumor patients was attributed to radiation therapy. In this article, we independently review the advances in clinical radiation oncology research which published by Chinese researchers. The major marked advances of radiation oncology that have the potential to lead to a reduction in mortality from cancers will be discussed.



Peritoneal Mesothelioma – A Review Concerning Surgical Management, Prognostic Factors, Future Advances and Our Experience in an Asian Population.

Dr Grace Hwei Ching Tan, Deanna Wan Jie Ng, Prof Khee Chee Soo, Dr. Melissa Ching Ching Teo

  1. Dr Grace Hwei Ching Tan
    MBBS (London), MRCS (Edinburgh)
    Registrar, Department of General Surgery, Singapore General Hospital.
  2. Deanna Wan Jie Ng
    Medical Student, Yong Loo Lin School of Medicine, National University of Singapore
  3. Prof Khee Chee Soo
    MBBS, MD, FRACS (Australia)
    Professor, Senior Consultant & Director, National Cancer Centre, Singapore
  4. Dr. Melissa Ching Ching Teo
    MBBS, FRCS (Edinburgh), MPH (Johns Hopkins)
    Senior Consultant, Department of Surgical Oncology, National Cancer Centre, Singapore,rnand Visiting Consultant, Department of General Surgery, Singapore General Hospital.

Mesothelioma is an aggressive neoplasm that develops from transformed cells originating in the mesothelium and is usually caused by exposure to asbestos. It most commonly occurs in the pleura and can also occur in the peritoneum, pericardium or tunica vaginalis. Peritoneal mesothelioma accounts for about one quarter of all mesotheliomas with three main pathological subtypes: epithelial, sarcomatous and mixed. Patients normally present with abdominal pain, distension, fever, diarrhea, ascites and weight loss. In the past, most treatment options included a combination of systemic chemotherapy, palliative surgery and in a few patients, abdominal radiation. Over the last decade, cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has been introduced as curative treatment with improved survival. This article aims to review the surgical management, prognostic factors affecting the prognosis of the disease as well as our experience with cytoreductive surgery and HIPEC for peritoneal mesothelioma in an Asian population.

Tobacco-attributed Cancer Incidence is Rising in Nepal Due to Increasing Prevalence of Tobacco Use: A Major Challenging Burden for Nepal

Dr Kalloo Sharma Subedi, Dr Progya Sharma

  1. Dr Kalloo Sharma Subedi
    M.D., D.M.R.D., Ph.D.
    Western Regional Hospital, Department of Radiology, Ramghat, Pokhara-10, Nepal.rnGunma University, Graduate School of Medicine, Department of Radiation Oncology, Maebashi Shi, 3-39-22, Showa-machi, Gunma – 371-8511, Japan.
  2. Dr Progya Sharma
    Manipal College of Medical sciences, Teaching Hospital, Fulbari, Pokhara, Gandaki Zone- 33700, Nepal

Cigarette smoking is a popular method of tobacco consumption worldwide. In Nepal, tobacco used in various forms such as Beedi smoking, a most popular form in Terai region followed by cigarette smoking and use of various smokeless tobacco preparations in hilly and urban areas. The prevalence of tobacco use is considerably higher in rural areas than in urban areas, particularly in youth population. Males more consume tobacco products than females. The prevalence of tobacco products users is the highest (68.2%) in the high mountain region followed by the Terai region (42.4%) and mid hilly region (40.9%). In Nepal, chronic non-communicable diseases of respiratory, cardio-vascular and, nervous systems, including cancers of oral cavity, respiratory and digestive organs, as well as premature deaths cause around 42% mortality. Tobacco is the most common risk factor, which became the world’s leading killer, responsible for many cancers. Lung cancer is the commonest tobacco-attributed cancer in both genders, which is one of the common causes of death from cancers in Nepal. The major part of population in Nepal is not aware of risk factors leading to cancers and other diseases. Therefore, fight against tobacco use becomes a challenging, difficult and more complex because of socio-cultural and economical factors. Long-term plans with effective actions are necessary to control the tobacco use and prevent more tobacco related deaths saving huge preventable expenses. The purpose of this study is to aware the people about the prevalence of tobacco use in Nepal and inspire to join the battle against tobacco use.

Death Auditing: Problems and Practical Solutions. 10 Year Cause-of-Death Analysis in Men Involved in a Trial of Intermittent Androgen Blockade for Prostate Cancer

Dr Caitlin McGregor, Dr Edward Wang, Dr Lauren Giudicatti, Dr. Nigel A. Spry, Dr. Raphael J. Chee

  1. Dr Caitlin McGregor
    University of Western Australia
  2. Dr Edward Wang
    University of Western Australia
  3. Dr Lauren Giudicatti
    University of Western Australia.
  4. Dr. Nigel A. Spry
    Clinical Professor Medicine, University of Western Australia, Edith Cowan University, Sir Charles Gairdner Hospital
  5. Dr. Raphael J. Chee
    Assistant Professor, School of Surgery, University of Western Australia,rnDirector of Radiation Oncology, Sir Charles Gairdner Hospital

Background: Death audits of prostate cancer trials provide both accurate cause-of-death analysis and flexible data collection, yet can be costly and time consuming. Therefore, identifying effective data collection strategies and solutions to frequently encountered problems may aid future prostate cancer trials. Methods: An expert panel collected and reviewed data relevant to cancer activity, including androgen independence and metastases, to determine cause-of-death for deceased patients from the 1998 multi-centre GUOG-IMAB prostate cancer trial as part of a late follow-up. Detailed records were kept regarding the different sources of patient information (general practitioners, enrolling specialists and other) as well as commonly encountered problems that impeded data collection. Results: Specialist practitioners were found to be the most useful initial contact, by providing sufficient data to determine cause-of-death in 69.3% of cases, compared to only 58.3% of general practitioners, but data collection was found to be less successful for practitioners assigned to multiple patients. The two most common problems found during data collection were the need to prompt practitioners on multiple occasions to obtain the requested information and a lack of up-to-date information when a patient had lost contact with their doctor. Conclusions: In future death audits involving comparable patient populations, it may be more time efficient and higher yielding to approach the enrolling specialist first, rather than other contacts, in requesting patient information. To overcome the most commonly encountered barriers to data collection, sending direct emails to the medical practitioner rather than contacting their practice may reduce the need for multiple prompting, whilst requesting the contact details of other care providers for each patient as standard protocol may mitigate the issues arising when patients have lost contact with one of their primary doctors. Furthermore, providing practitioners who have a high patient load with a pre-prepared template for direct data entry may increase response rates and time efficiency.

Sociodemographic Characteristics of Cancer Patients: Hospital Based Cancer Registry in a Tertiary Care Hospital of India

Dr Sonia Puri, Dr Amarjit Singh, Dr Munish Ashat, Dr. Naveen Goel, Dr. Avadesh Pandey

  1. Dr Sonia Puri
    Assistant Professor, Dept. of Community Medicine,rnGovt Medical College and Hospital, Chandigarh, India.rn
  2. Dr Amarjit Singh
    MBBS, MD,
    Professor, School of Public Health, PGIMER, Chandigarh, India
  3. Dr Munish Ashat
    GMCH-32, Chandigarh, India
  4. Dr. Naveen Goel
    MBBS, MD
    Professor, Dept. of Community Medicine, GMCH-32, Chandigarh, India
  5. Dr. Avadesh Pandey
    MBBS, MD
    Associate Professor, Dept. of Radiotherapy, GMCH 32, Chandigarh., India

Aim: To determine the socio-demographic characteristics of cancer patients. Method: Review of the Cancer registry, and patient interview. Information on socio demographic profile, medical history, family history and previous treatment, if any, was retrieved from the patient. If the patient couldn’t be contacted then information was taken from pathology / radiotherapy or medical records department. Result: A total of 684 patients participated in the study. More than 40% subjects were illiterate. And majority of them were of low socioeconomic status. Maximum cases getting registered were from neighbouring state Haryana(276;44.4). The most frequently reported cancer(ca) in males was ca lung (113;40.9) and ca oesophagus (32;9.8). In females, most common cancer was ca breast(86;23.9) followed by ca cervix (42;11.7).

Study on Health-Related Quality of Life in Bone Cancer Patients

Cheah Whye Lian, Soh Mei Hua, Chang Ching Thon

  1. Cheah Whye Lian
    PhD (Community Nutrition)
    Department of Community Medicine, Faculty of Medicine & Public Health, UNIMAS, Sarawak, Malaysia;
  2. Soh Mei Hua
    Diploma in Nursing
    Department of Orthopedics, Faculty of Medicine & Public Health, UNIMAS, Sarawak, Malaysia;
  3. Chang Ching Thon
    PhD (Community Health)
    Deparment of Nursing, Faculty of Medicine & Public Health, UNIMAS, Sarawak, Malaysia.

Background and Objectives : Like any other cancers treatment, bone cancer patients undergo pain and suffering that may compromise their functional status, ability to adjust and subsequently quality of life. This study aimed to investigate the impact of bone cancer on quality of life among bone cancer patients. Materials : This cross-sectional study was conducted at Sarawak General Hospital, Kuching, Sarawak. Bone cancer patients were interviewed using a pretested 30-item questionnaire adopted from EORTC (European Organization for Research and Treatment of Cancer). Data was analysed using SPSS software. Results : A total of 50 respondents was recruited during the two months data collection. Majority of the patients are aged 40 years and below, 54% were females, 28% were Malays, 60% were married. Majority of the respondents were studying or working, 54% had education up to secondary level and higher. The mean QoL score for global health status was 53.8 ± 14.6. The highest score on the functional scale was for Physical functioning (71.0 ± 20.5), followed by Cognitive functioning (70.3 ± 27.2). Under Symptom scales, the highest score was Financial difficulties (64.6 ± 28.0), followed by Appetite loss (51.3 ± 25.3), Insomnia (50.6 ± 23.5), and others with Dyspnoea having the lowest mean score (5.66 ± 9.88). Conclusion : Overall bone cancer patients perceived their quality of life to be lower. Sustained problems such as emotional functioning, social functioning, nausea and vomiting, appetite loss and financial difficulties were observed. Appropriate interventional programmes should be designed to help these patients to improve their overall quality of life.

Male Genital Tract Tumours: A Study of 2149 Cases at AFIP, Rawalpindi, Pakistan

Dr Shahid Jamal, Dr Muhammad Atique, Dr Muhammad Tahir Khadim, Dr. Shoaib Naiyar Hashmi, Dr. Hafeez Ud Din, Dr. Farhan Akhtar

  1. Dr Shahid Jamal
    Histopathology Department, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan
  2. Dr Muhammad Atique
    Histopathology Department, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan
  3. Dr Muhammad Tahir Khadim
    Histopathology Department, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan
  4. Dr. Shoaib Naiyar Hashmi
    Histopathology Department, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan
  5. Dr. Hafeez Ud Din
    Histopathology Department, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan
  6. Dr. Farhan Akhtar
    Histopathology Department, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan

Objective: To study the frequency and distribution of male genital tract malignancies in Northern Pakistan. Study design: Cross sectional descriptive Place and duration of study: Armed Forces Institute of Pathology (AFIP) Rawalpindi, from 2002-2011 Material and methods: Total of 2149 cases of malignant tumours of male genital tract tumours were retrieved from AFIP tumour registry and data analysis was done using computer software SPSS 12. Mean ±SD was calculated for age of the patients. Frequencies were calculated for gender of the patients and site of the tumour. Results: Total 32718 malignant cases were reported at AFIP from 2002-2011, out of which 2149 (11.2% of all male malignancies) were of male genital tract. Carcinoma prostate was the most frequent (84.9%) followed by tumours of the testis (13.5%). Carcinoma of the penis was found in only 9 (0.4%) cases. The prostatic tumours were more in elderly patients, mostly after the age of 60, and testicular tumours were more in younger age group. The histological pattern for prostate was predictable, and germ cell tumours were most frequent of testicular tumours followed by Non Hodgkin lymphoma. Conclusion: Carcinoma prostate was most frequent of male genital tract cancer followed by testicular tumours. The germ cell tumours followed by non Hodgkin lymphoma were main testicular tumours. Penile tumours are very low possibly due to early circumcision.

« View All Issues