Issue: Vol.6, No.1 - January 2007

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Article Type: Editorial

Austral - Asian Journal of Cancer(AJC) from the modest of beginning has become a reputed international journal covering articles from well-known international authors. The editorial board is confident that in the coming years, AJC will serve as a platform for exhibiting and sharing of various interesting articles amongst the clinicians and scientists.

In this edition we have included articles covering a wide range of topics from clinical and molecular aspects of cancer to chemotherapeutic trials.

Neuroblastoma is one of the commonest solid childhood tumors. Genetic alteration play an important role in the development and progression of the diseases. The article 'The Enigmatic Role of p16CDKN2/INK4a in Neuroblastoma: An Enigma of Expressive Proportions', deals with the role of p16 and other cyclin dependent kinase inhibitors in the development of neuroblastoma.

Liquid chromotography/mass spectometic assey is a novel test to assess various drug interactions for many anticancer agents. The article 'Analysis of Potential Drug - Drug Interactions for Anti-cancer Agents in Human Liver Microsomes by High Throughput Liquid Chromatography/ Mass Spectrometry Assay', deals with this specific and reproducible method to determine inhibition of multiple CYP enzymes in a single array. This technique is also a useful tool for screening anticancer compounds for clinically relevant drug interactions.

Dermatofibroma (DF) and Dermatofibrosarcoma Protuberans (DFSP) are rare tumor of dermis. The differential diagnosis in most of the cases are straight forward by routine H/E sections. In doubtful cases immunohistochemistry is also useful. In the article 'Dermatofibrosarcoma Protuberans and Dermatofibroma: Dermal Dendrocytomas: An Ultra-structural Study', the authors have analyzed the ultra-structural characteristics of Dermatofibrosarcoma Protuberans and Dermatofibroma has come out with valuable information to differentiate both.

Uterine Leiomyomas are benign tumors of the uterus. Often patients are asymptomatic. In spite of this, the uterine leiomyomas can cause significant morbidity. In the article 'Uterine Leiomyoma: Updates in Cytogenetics and Molecular Analysis', the authors have analyzed the cytogenetics and molecular aspects of uterine leiomyoma in detail.

Nondysgerminomatous ovarian tumors are relatively rare tumors seen in adolescents and young women. Conservative surgery is the standard treatment for most of the patients. In the article 'Non-dysgerminomatous Ovarian Tumors: Clinical Characteristics, Treatment and Outcome', the authors have done a retrospective analysis of clinical characteristics, treatment outcome and prognostic factors of non-dysgerminomatous ovarian tumors from their institution.

Metastatic colorectal carcinoma carries a poor prognosis. However, recent advancements in chemotherapeutic drugs have improved the median survival of these patients. Many newer chemotherapeutic durgs have shown to improve the survival in these patients. In the article 'Comparison of 5-Flourouracil and Leucovorin, Versus 5-Flourouracil, Leucovorin and Oxaliplatin, in Metastatic Colorectal Malignancy', the authors have compared 5-Flourouracil and Leucovorin, Versus 5- Flourouracil, Leucovorin and Oxaliplatin, in metastatic colorectal cancer and has concluded that addition of oxaliplatin improves the overall survival as well as response rate of metastatic colorectal carcinoma.

Inflammatory bowel disease carries a significant morbidity. Many a times, correct diagnosis is difficult. In the article 'Twin Studies in Inflammatory Bowel Disease. A Review', the authors have analysed in depth, the pathogenesis of IBD and has concluded that genetic and environmental factors should also be evaluated in the aetiology of inflammatory bowel diseases (IBD).

We hope all of you will like the vast range of contents in this issue. Readers comments and suggestions for further improvements are always welcome. We take this opportunity to wish all our readers "a prosperous and happy New Year".


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