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Superselective Arterial Cisplatin Infusion with Concomitant Radiation Therapy for Advanced Nasal Cavity and Paranasal Sinus Carcinoma

Issue: Vol.11, No.1 - January 2012

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Article Type: Manuscript

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  1. Dr Akihiro Homma
    M.D.; Ph.D
    Department of Otolaryngology - Head & Neck Surgery, Hokkaido University Graduate School of Medicine

Intra-arterial infusion of chemotherapy agents for cancer of the head and neck has been used for several decades. Subsequent advances in vascular radiology techniques have enabled superselective arterial infusion to head and neck structures, and a specific concomitant chemotherapy protocol for head and neck cancer that employs the pharmacologic principles of IA cisplatin while capitalizing on the cisplatinneutralizing agent sodium thiosulfate has shown promising results. This article provides the historical background, rationale, and current state of our research on the use of this treatment regimen for patients with advanced nasal and paranasal sinus carcinoma.

 Intra-arterial infusion of chemotherapy agents for cancer of the head and neck has been used for several decades. This article provides the historical background, rationale, and current state of our research on the use of this treatment regimen for patients with advanced nasal and paranasal sinus carcinoma.1

 

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