Recent Advances in Nephrogenetics and Molecular Diagnostics: Are Current Approaches Becoming Obsolete?
Issue: Vol.8, No.4 - October 2009
Article Type: Manuscript
Molecular diagnostics is a promising scientific sector on the rise, enhanced to a great extent by technological developments. Massive mutation screening methods and direct automated DNA sequencing have enabled researchers and diagnostics laboratories to identify frequent and rare genetic defects, thus contributing to medical translational research. Despite all the progress, the complexity of gene systems, even of monogenic disorders, makes molecular testing a formidable task, especially for relatively small molecular medicine laboratories. Nephrogenetics is one such field where genetic and consequent phenotypic heterogeneity are particularly complex, with tens of genes involved and interacting, often times in unpredictable ways, to cause disease. It turns out that useful approaches of the older generation will continue to be useful for many years to come, while supported and facilitated by more recent and advanced high throughput technologies.
Also In This Issue
- Editorial: Fatigue, the Most Common Problem within People Afflicted with Cancer: Challenge for Health Care Professionals - Widening Our Perspectives on Existential Issues
- Profile: Dr. Ilja Frank Ciernik
- Benign Granular Cell Tumor of the Soft Tissue of the Pelvis
- Serum Transaminases Ratio in Breast Cancer Patients
- Aberrant Methylation of Pyk2 Gene Promoter Influences its Expression in Gastric Cancer Cell
- Profile of Pediatric Cancer Patients Treated with External Beam Radiation Therapy Under Anesthesia at a Regional Cancer Center of India
- Syndrome of Inappropriate Antidiuretic Hormone Secretion Complicated with Stem Cell Transplantation
- Cancer Patients' Opinions Concerning Post-Treatment Follow-up
- Metastatic Bone Disease: A Review of Literature
- Retroperitoneal Sarcomatoid Variant of Diffuse Large B-Cell Lymphoma: A Case Report
