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Progress in Radiation Therapy for Esophageal Cancer

Issue: Vol.4, No.2 - April 2005

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Article Type: Manuscript

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  1. Dr Yasumasa Nishimura
    MD
    Department of Radiation Oncology; Kinki University School of Medicine,

In this review , recent progress in radiation therapy (RP) for esophageal cancer was presented. First, Radio-sensitization by concurrent use of chemotherapy (CT) was clinically proved by several randomized clinical trials for locally advanced esophageal cancer. At present, concurrent 5-FU /cisplatin combined with RT is standard CT-RT regimen for advanced esophageal cancer. Second, improvement in spatial dose distribution for esophageal cancer was obtained by intraluminal brachytherapy (IBT)and conformal RT including intensity modulated RT (IMRT). IBT boost following external Rtis an effective modality in the treatment of superficial esophageal cancer. IMRT is an ideal boost technique for locally advanced cervical and upper thoracic esophageal cancers to exclude the spinal cord. Third improvement in time-dose-fractionation was achieved by accelerated hyperfractionation (AHF). Shortening overall treatment time by AHF is an effective strategy for esophageal cancer.

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