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Molecular and Biological Study on the Soluble Intercellular Adhesion Molecule-1 ICAM-1 in Breast Cancer Patients

Issue: Vol.10, No.3 - July 2011

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  1. Dr Ali S. Alshehri
    King Khalid University, Faculty of Science, Biology Department,

Breast cancer is the most common form of cancer amongst females and the main problem associated with the management of breast cancer is metastasis. Breast cancer patients and benign lesions were recruited from those scheduled for lumpectomy or modified radical mastectomy. Soluble ICAM-1 (sICAM-1) was assayed in the mRNA preparations of peripheral blood mononuclear cells isolated from all subjects under study by the Real time PCR (RT -PCR). The expression of sICAM-1 in different stages of breast cancer patients was, the mean of 279.14 ±4.37 ng/ml (S.D 40.99) in stages I, the mean of 344.5 ±3.84 ng/ml (S.D 48.68) in stages II, the mean of 409.1 ±4.11 ng/ml (S.D 66.44) in stages III, and finally the mean of 450 ±4.33ng/ml (S.D 198.1) in stages I respectively. The statistical analysis of these data revealed a gradual and significant elevation in the expression of sICAM-1 in different stages of breast cancer patients when compared with benign breast patients and negative controls. (F = 4.583, P < 0.001). Breast tumors encountered at younger ages and in premenopausal women are more aggressive, whilst women who are diagnosed with breast cancer after the menopause have a better prognosis. The augmented expression of sICAM-1 by PBMCs of breast cancer patients is positively influenced by the estrogen phenotype, tumor grade and regional lymph node status. Assessment of sICAM-1 might play a pivotal role as a sensitive PBMC- based biomarker in breast cancer prognosis and follow up.

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