In Vitro Interaction of Cyclooxygenase - 2 Inhibitors with Radiation in Nasopharyngeal Carcinoma Cell line: Dependence on Sequence of Administration
Issue: Vol.11, No.1 - January 2012
Article Type: Manuscript
In nasopharyngeal carcinoma (NPC), COX-2 inhibitors have been reported to exhibit dose-dependent growth inhibition of these cancer cells, but their interaction with radiation has yet been studied. Here, we examined the effects of selective COX-2 inhibitors SC-236 and NS-398 on the radiosensitivity of NPC cells. When incubated with COX-2 inhibitors prior to irradiation, increased radiation cell kill was documented. However, when the sequence of COX-2 administration was reversed, we observed radioprotection instead. Our findings hereby confirmed the enhancement effect of COX-2 inhibitors on radiation cell kill in vitro, but this effect is critically dependent on their sequence of administration.
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- Profile ----- Prof. Rodney J Scott
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