In Vitro Interaction of Cyclooxygenase - 2 Inhibitors with Radiation in Nasopharyngeal Carcinoma Cell line: Dependence on Sequence of Administration
Issue: Vol.11, No.1 - January 2012
Article Type: Manuscript
In nasopharyngeal carcinoma (NPC), COX-2 inhibitors have been reported to exhibit dose-dependent growth inhibition of these cancer cells, but their interaction with radiation has yet been studied. Here, we examined the effects of selective COX-2 inhibitors SC-236 and NS-398 on the radiosensitivity of NPC cells. When incubated with COX-2 inhibitors prior to irradiation, increased radiation cell kill was documented. However, when the sequence of COX-2 administration was reversed, we observed radioprotection instead. Our findings hereby confirmed the enhancement effect of COX-2 inhibitors on radiation cell kill in vitro, but this effect is critically dependent on their sequence of administration.
Also In This Issue
- Editorial ----- Recognition and Treatment of Malignant Brain Tumors in Develping Countries: How can we improve current outcomes?
- Profile ----- Prof. Rodney J Scott
- Fractal Analysis in the Study of Oral Cancer
- Incidence and Significance of Supplement-Drug Interactions in Oncology Patients at an Integrative Medicine Center
- Superselective Arterial Cisplatin Infusion with Concomitant Radiation Therapy for Advanced Nasal Cavity and Paranasal Sinus Carcinoma
- Treatment of Liver Metastases from Neuroendocrine Tumors in Relation to the Extent of Hepatic Disease
- Effects of Helicobacter Pylori Infection on Genetic Instability, The Aberrant CpG Island Methylation Status and The Cellular Phenotype in Barrett\'s Esophagus in a Japanese Population
- Current Diagnosis and Treatment of Diseases of the Thoracic and Thoracoabdominal Aorta Amenable to Surgery
