Print

In Vitro Interaction of Cyclooxygenase - 2 Inhibitors with Radiation in Nasopharyngeal Carcinoma Cell line: Dependence on Sequence of Administration

Issue: Vol.11, No.1 - January 2012

« Back to Articles

Article Type: Manuscript

Download PDF Version »

  1. Dr Melvin Lee Kiang Chua
    Department of Cancer Institute, University College London Cancer Institute,
  2. Dr Haslinda Binte Kamis
    Department of Radiation Oncology, National Cancer Centre,
  3. Dr Jonathan Yi Hui Teh
    Department of Radiation Oncology, National Cancer Centre,
  4. Dr Susan Li Er Loong
    Divison of Cellular and Molecular Research, National Cancer Centre,

In nasopharyngeal carcinoma (NPC), COX-2 inhibitors have been reported to exhibit dose-dependent growth inhibition of these cancer cells, but their interaction with radiation has yet been studied. Here, we examined the effects of selective COX-2 inhibitors SC-236 and NS-398 on the radiosensitivity of NPC cells. When incubated with COX-2 inhibitors prior to irradiation, increased radiation cell kill was documented. However, when the sequence of COX-2 administration was reversed, we observed radioprotection instead. Our findings hereby confirmed the enhancement effect of COX-2 inhibitors on radiation cell kill in vitro, but this effect is critically dependent on their sequence of administration.

 

Download PDF Version »

Favourites   Share / Bookmark

Also In This Issue

« Back to Articles