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Expression of p53, Ki-67 and bcl-2 Oncoproteins in Human Breast Cancer and their Clinicopathologic

Issue: Vol.3, No.4 - October 2004

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Article Type: Manuscript

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  1. Prof Ephata E. Kaaya
    Department of Pathology, Muhimbili University College of Health Sciences,
  2. Qiangxiu Wang
  3. Lihua Chen
  4. Jiayao Wang

Breast cancer is the leading cancer site in women, both in the developed and the developing world. The incidence of breast cancer has been increasing in recent years in China. In order to study the interrelation between mutant p53, Ki-67 and bcl2 proteins, and their clinicopathologic significance in breast cancer, 69 cases of breast carcinoma were investigated using LSAB immunohistochemical method. Nuclear staining of mutant p53 and Ki?67 were observed in 26% and 39% of specimens, respectively. Cell cytoplasm staining of bcl-2 protein was observed in 36% of specimens. Expression of mutant p53 was associated with older patients (P=0.011). The observed strong relationship between the expression of p53, Ki-67 and bcl-2 proteins with disease duration suggests that patients who present late to hospital tend to have tumors with high proliferating rate which are also more aggressive. Statistically significant correlation was detected between the frequency of expression of p53, Ki-67, or bcl-2 protein and tumor grading. These results suggest that p53, Ki-67 and bcl-2 proteins are involved in tumorigenesis and development of breast cancer with different biological behavior. Therefore assessment for expression of p53, Ki-67 and bcl-2 oncoproteins can be used as prognostic markers in breast cancer and are of significance in determining and planning management of patients.

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