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A Combination of Ondansetron, Metoclopramide, Dexamethazone and Lorazepam for the Prevention of Irinotecan Induced Nausea and Vomiting

Issue: Vol.4, No.2 - April 2005

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Article Type: Manuscript

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  1. Dr Gerasimos Aravantinos
    Karaoli Dimitriou 11,
  2. Dr I Sgouros
    3rd Dept of Internal Medicine and Clinical Oncology, \"Ag. Anargiri\' Cancer Hospital
  3. Dr M Kostopoulou
    3rd Dept of Internal Medicine and Clinical Oncology, \"Ag. Anargiri\' Cancer Hospital
  4. Dr V Kostopoulos
    3rd Dept of Internal Medicine and Clinical Oncology, \"Ag. Anargiri\' Cancer Hospital
  5. Dr A Zafiropoulos
    3rd Dept of Internal Medicine and Clinical Oncology, \"Ag. Anargiri\' Cancer Hospital
  6. Dr A Konstantinidou
    3rd Dept of Internal Medicine and Clinical Oncology, \"Ag. Anargiri\' Cancer Hospital
  7. Dr J Janinis
    3rd Dept of Internal Medicine and Clinical Oncology, \"Ag. Anargiri\' Cancer Hospital
  8. Dr D Makridaki
    3rd Dept of Internal Medicine and Clinical Oncology, \"Ag. Anargiri\' Cancer Hospital

Background: Irinotecan (CPT-11) has been proven effective in colorectal cancer and other tumors. Therefore its use is increasing. Unfortunately Irinotecan is highly emetogenic. This study was conducted to evaluated the effectiveness of the combination of ondansetron, metoclopramide, dexamethasone and  lorazepam in the prevention of CPT-11 induced nausea and vomiting.

Patients and Methods: Patients with metastatic colorectal cancer who received CPT-11at the dose of 350mg/m2 every three weeks were entered in the study. The anti-emetic regimen consisted of 16mg Ondansetron, 8mg dexamethasone, 8mg dexamethasone and 2.5 mg lorazepam prior to the administration of the chemotherapy on day 1 and the administration of 16mg ondansetrom and 30mg metocloprmide daily for the days 2-4.

Results: twenty-nine patients were enrolled. Complete control of nausea and vomiting was achieved in 15 patients (52%). Three patients (10%) experienced grade 1 and 14

Conclusion: The combination of ondansetron, metoclopramide, dexamethasone and lorazepam gives promising results in the control of nausea and vomiting in patients with metastatic colorectal cancer treated with CPT-11.

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